Schizophrenia is a neuropsychiatric disorder featuring recurrent episodes of psychosis — such as hallucinations, delusions, and disorganized thinking — with many patients developing apathy, social withdrawal, and poor emotional control as a result.

Because schizophrenia has been known to run in families for centuries, researchers have turned to genetic testing and analyses to identify risk factors for the condition. Recent genomic research on schizophrenia has identified nearly 300 common genetic variants and over 20 rare variants as significant risk factors for the disorder.

These discoveries have emerged from extensive genome-wide association studies, whole-exome sequencing, and other analyses. Simultaneously, studies of the functional organization of the brain have shed light on the intricate cellular composition and interconnections of the brain in both neurotypical individuals and those with schizophrenia.

These findings reveal a surprising complexity in the mechanisms underlying schizophrenia, emphasizing the role of multiple genes rather than single-gene causation. This “polygenicity” highlights a mechanism that remains challenging to fully understand due to the lack of robust theoretical frameworks and experimental tools. Sullivan and colleagues reviewed these issues and provided ideas for a path forward in the Nature Reviews Neuroscience article.

However, Sullivan and colleagues stress that environmental factors (including lifestyle, drug use, poverty, stress, and complications at birth) are also relevant in addition to genomic risk. Although these factors are more difficult to study compared to the genome, this genetic information is important for researchers to consider because some environmental factors are modifiable.

“The findings to date resoundingly indicate complexity,” wrote Sullivan, who is also director of the UNC Center for Psychiatric Genomics and the UNC Suicide Prevention Institute. “Rather than being a deterrent to future research, this knowledge underscores the importance of accepting schizophrenia as a genetic and environmental enigma and scaling our research accordingly in our efforts improve the lives of those impacted by schizophrenia.”

Long COVID, also known as Post-COVID-19 condition, is generally defined as symptoms persisting for three months or more after acute COVID-19. The condition can affect and damage many organ systems, leading to severe and long-term impaired function and a broad range of symptoms, including fatigue, cognitive impairment — often referred to as ‘brain fog’ — breathlessness and pain.

Long COVID can affect almost anyone, including all age groups and children. It is more prevalent in females and those of lower socioeconomic status, and the reasons for such differences are under study. The researchers found that while some people gradually get better from long COVID, in others the condition can persist for years. Many people who developed long COVID before the advent of vaccines are still unwell.

“Long COVID is a devastating disease with a profound human toll and socioeconomic impact,” said Janko Nikolich, MD, PhD, senior author of the paper, director of the Aegis Consortium at the U of A Health Sciences, professor and head of the Department of Immunobiology at the U of A College of Medicine — Tucson, and BIO5 Institute member. “By studying it in detail, we hope to both understand the mechanisms and to find targets for therapy against this, but potentially also other infection-associated complex chronic conditions such as myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia.”

If a person has been fully vaccinated and is up to date with their boosters, their risk of long COVID is much lower. However, 3%-5% of people worldwide still develop long COVID after an acute COVID-19 infection. According to the Centers for Disease Control and Prevention, long COVID affects an estimated 4%-10% of the U.S. adult population and 1 in 10 adults who had COVID develop long COVID.

The review study also found that a wide range of biological mechanisms are involved, including persistence of the original virus in the body, disruption of the normal immune response, and microscopic blood clotting, even in some people who had only mild initial infections.

There are no proven treatments for long COVID yet, and current management of the condition focuses on ways to relieve symptoms or provide rehabilitation. Researchers say there is a dire need to develop and test biomarkers such as blood tests to diagnose and monitor long COVID and to find therapies that address root causes of the disease.

People can lower their risk of developing long COVID by avoiding infection — wearing a close-fitting mask in crowded indoor spaces, for example — taking antivirals promptly if they do catch COVID-19, avoiding strenuous exercise during such infections, and ensuring they are up to date with COVID vaccines and boosters.

“Long COVID is a dismal condition but there are grounds for cautious optimism,” said Trisha Greenhalgh, lead author of the study and professor at Oxford’s Nuffield Department of Primary Care Health Sciences. “Various mechanism-based treatments are being tested in research trials. If proven effective, these would allow us to target particular subgroups of people with precision therapies. Treatments aside, it is becoming increasingly clear that long COVID places an enormous social and economic burden on individuals, families and society. In particular, we need to find better ways to treat and support the ‘long-haulers’ — people who have been unwell for two years or more and whose lives have often been turned upside down.”

The full paper, “Long COVID: a clinical update,” is published in The Lancet.

Despite feeling like a stationary mass, most solid ground is undergoing a process of deformation, sinking and rising in response to many environmental factors. In Antarctica, melting glacial ice means less weight on the bedrock below, allowing it to rise. How the rising earth interacts with the overlying ice sheet to affect sea level rise is not well-studied, said Terry Wilson, co-author of the study and a senior research scientist at the Byrd Polar and Climate Research Center at The Ohio State University.

In the new study, Wilson’s colleagues at McGill University developed a model to predict how these interactions could impact global sea level, finding that if humans can lower greenhouse gas emissions and global warming is slowed, upward shifts in the solid earth could reduce Antarctica’s contribution to sea level rise by about 40%, significantly bolstering the best case scenarios for global sea level rise. In this low-emissions scenario, land uplift slows the flow of ice from land to ocean, allowing for more of the ice sheet to be preserved.

Conversely, if humans are unable to lower carbon emissions in time, ice retreat will outpace uplift, pushing ocean water away from Antarctica and amplifying sea level rise. These events could significantly worsen the most dire models of projected sea level rise along populated coastlines, said Wilson.

“Our measurements show that the solid earth that forms the base of the Antarctic ice sheet is changing shape surprisingly quickly,” said Wilson. “The land uplift from reduced ice on the surface is happening in decades, rather than over thousands of years.”

The study was published today in Science Advances.

To arrive at these conclusions, the team developed a 3D model of the Earth’s interior using geophysical field measurements from the Antarctic Network (ANET) of the Polar Earth Observing Network (POLENET) project. The mission is focused on studying the changing polar regions by collecting GPS and seismic data from an array of autonomous systems across Antarctica.

Researchers then performed a number of simulations to capture many possible evolutions of Antarctica’s ice sheet and the extent of global sea level rise Earth may experience until the year 2500, according to those parameters.

“We can project what difference it actually will make if we all contribute to a low-emission scenario now, versus what’s come to be called ‘business as usual’ emissions,” said Wilson, who is also the lead investigator of the ANET-POLENET project.

She attributes the model’s unprecedented level of detail to how deftly it incorporates data from Antarctica. GPS stations monitor how the land is moving and seismometers measure how fast seismic waves from earthquakes travel through the earth, yielding important insight into where the land uplift will be fast or slow.

Surprisingly, according to some of the team’s GPS observations processed by researchers at Ohio State, Wilson said, the Antarctic Ice Sheet is currently experiencing a solid earth uplift of about 5 centimeters per year, about 5 times the rate that North America experiences.

Another significant aspect of the study is how the changes in Antarctica under different carbon emissions scenarios will impact coastlines around the world. Because sea level change will not be uniform, the study notes that nearly 700 million people around the world living in coastal regions will be most impacted by rising seas due to Antarctic ice loss.

Since some regions, such as small island nations, will be more vulnerable than others, mitigating environmental conditions like atmospheric and ocean warming is a vital issue for society, said Wilson.

“Many people are now more aware they’re experiencing the effects of climate change,” she said. “This work reinforces that our actions as individuals, nations and globally can make a difference in what kind of Earth our offspring will experience in their lifetimes.”

The study results highlight how complex the relationship between the solid earth and the processes that happen atop it is, as well as the importance of continuing to gather enough data to make prompt and accurate predictions about what the next few centuries of our planet will look like.

“There’s a lot of uncertainty in every model and every prediction that you make,” said Wilson. “But to document how fast our world is changing, it’s very important to continue advancing our ability to make predictions that are more certain, which is the only path that will allow us to tend to our future in a meaningful way.”

Wilson completed the study with colleagues from McGill University, Pennsylvania State University, the University of Massachusetts Amherst, Columbia University, Washington University, Colorado State University and the Union of Concerned Scientists. This study was supported by the U.S National Science Foundation and the Natural Sciences and Engineering Research Council of Canada.

“The improvements we saw on both printability and mechanical measures suggest that incorporating cellulose nanofibrils in commercial printable materials could lead to more resilient and eco-friendly construction practices sooner rather than later,” said Osman E. Ozbulut, a professor in the Department of Civil and Environmental Engineering.

His team’s findings will be published in the September 2024 issue of Cement and Concrete Composites.

Buildings made of 3D-printed concrete are an exciting trend in housing, and they offer a slew of benefits: Quick, precise construction, possibly from recycled materials, reduced labor costs and less waste, all while enabling intricate designs that traditional builders would struggle to deliver.

The process uses a specialized printer that dispenses a cement-like mixture in layers to build the structure using computer-aided design software. But so far, printable material options are limited and questions about their sustainability and durability remain.

“We’re dealing with contradictory objectives,” Ozbulut said. “The mixture has to flow well for smooth fabrication, but harden into a stable material with critical properties, such as good mechanical strength, interlayer bonding and low thermal conductivity.”

Cellulose nanofibrils are made from wood pulp, creating a material that’s renewable and low impact. Like other plant-fiber derivatives, CNF, as the material is known in industry, shows strong potential as an additive to improve the rheology — the scientific term for flow properties — and mechanical strength of these composites.

However, until the UVA-led team’s meticulous study in Ozbulut’s Resilient and Advanced Infrastructure Lab, the influence of CNF on conventional 3D-printed composites wasn’t clear, Ozbulut said.

“Today, a lot of trial and error goes into designing mixtures,” he said. “We’re addressing the need for more good science to better understand the effects of different additives to improve the performance of 3D-printed structures.”

Experimenting with varying amounts of CNF additive, the team, led by Ozbulut and Ugur Kilic, now a Ph.D. alumnus of UVA, found that adding at least 0.3% CNF significantly improved flow performance. Microscopic analysis of the hardened samples revealed better material bonding and structural integrity.

In further testing in Ozbulut’s lab, CNF-enhanced 3D-printed components also stood up to pulling, bending and compression.

The finding is significant because the Antarctic Ice Sheet is the largest ice mass on Earth, and the biggest uncertainty in predicting future sea levels is how this ice will respond to climate change.

“With nearly 700 million people living in coastal areas and the potential cost of sea-level rise reaching trillions of dollars by the end of the century, understanding the domino effect of Antarctic ice melt is crucial,” said lead author Natalya Gomez, an Associate Professor in McGill’s Department of Earth and Planetary Sciences and Canada Research Chair in Ice sheet — Sea level interactions.

The study focuses on how the ice sheet interacts with the earth beneath, and how that dynamic is influenced by carbon-emission levels. This relationship has not been thoroughly explored in previous studies, the researchers said.

“Our findings show that while some sea level rise is inevitable, swift and substantive action to lower emissions could prevent some of the most destructive impacts of climate change, particularly for coastal communities,” Gomez said.

Rising seas and nature’s double-edged sword

As ice melts, its weight decreases, causing the land beneath it to rise like an expanding sponge. The researchers say this process, called post-glacial uplift, can be a double-edged sword.

If emissions drop quickly, limiting global warming, post-glacial uplift can act as a natural brake on ice-mass loss. It lifts the ice up, slowing the flow of ice from land to ocean. The study found this dynamic can reduce Antarctica’s contribution to sea- level rise by up to 40 per cent.

However, if carbon outputs keep pace and the planet heats up quickly, the rebounding land will not be enough to slow the rapidly melting ice, and instead pushes more ocean water away from Antarctica, accelerating sea-level rise along populated coastlines.

To reach their findings, Gomez and collaborating scholars from Canada and the United States developed a 3-D model of Earth’s interior. Their model used geophysical field measurements from the U.S. ANET-POLENET project, which had pioneered large-scale deployments of sensitive instruments to record the bedrock uplift and seismic signals across large expanses of Antarctica. These extensive field measurements were essential for characterizing the three-dimensional variations of the Antarctic mantle incorporated in the study.

“Our 3-D model peels back Earth’s layers like an onion, revealing dramatic variations in thickness and consistency of the mantle below. This knowledge helps us better predict how different areas will respond to melting,” said co-author Maryam Yousefi, a geodesist at Natural Resources Canada and previously a Postdoctoral Fellow at McGill and Penn State universities.

It’s the first model to capture the relationship between Antarctica’s ice and underlying earth in such detail, she added.

Notes Rob DeConto, a co-author and glaciologist at the University of Massachusetts, “This study marks a breakthrough in our ability to better predict the impacts of climate change on rising seas and to inform effective environmental policy.”

Global impacts

The findings, published in Science Advances, highlight the inequalities of climate change, the scholars noted. Island nations, which contribute the least to global emissions, are likely to bear the brunt of their consequences, they said.

The study is a collaboration between researchers at McGill, Pennsylvania State, Cambridge, Columbia, Colorado State, Ohio State, the University of Massachusetts Amherst, the University of Washington and the Union of Concerned Scientists. It was funded by the Canadian Natural Sciences and Engineering Research Council, the U.S. National Science Foundation and the Canada Research Chairs program.

Cats have a more acute sense of smell than humans, and the aroma of their food plays a big role in whether they’ll eat or snub what their owner serves for dinner. Feline palates are also more sensitive to umami (savory) flavors than humans, and they can’t taste sweetness. While meat-flavored food attractant sprays can help improve the scent and tastiness of dry kibble, the exact correlation between volatile flavor compounds and palatability is not well understood. Additionally, previous studies in this area lack input from a very important focus group: actual cats! So, Shiqing Song and colleagues relied on the expertise of a panel of 10 hungry adult cats to evaluate a series of food sprays containing different volatile flavor compounds.

To prepare their fragrant sprays, the researchers homogenized and heat-treated chicken livers. Then, they broke down proteins in the liver paste to various degrees using enzymes to produce four different food attractants. Song’s team identified over 50 different flavor compounds across the sprays, ranging from tropical and floral to sweaty and rubbery. For the taste test, the researchers coated commercially available cat food with chicken fat and then sprayed it with one of the four chicken liver attractants. The samples were presented to the cats alongside a control food treated with a different, commercially available attractant. The team observed which bowl the cats chose first and how much food they ate throughout the day.

The researchers found that most cats preferred and ate more of the foods sprayed with their attractants, particularly the sprays with proteins that were further broken-down by the enzymes and contained more free amino acids. These compounds are important flavor precursors that can undergo the Maillard reaction, which likely produced many different aroma-enhancing compounds during the heat treatment step. The favored foods contained more mushroom and fatty flavors as well, while the less-enjoyed foods featured acidic- and sweet-tasting compounds, possibly because fewer Maillard reactions occurred. This work could help inform future cat food formulations and increase your chances of choosing a kibble your finicky feline might enjoy.

The authors acknowledge funding from the Natural Science Foundation of Shanghai and thank their feline volunteers for their participation.