Lena Dunham has confirmed that she’s currently working on five brand new episodes of the award-winning 2010s series, bringing Allison Williams, Jemima Kirke, Zosia Mamet and Andrew Rannells along for the ride, with production getting underway in the summer of 2027.
“We always said we would only return to Girls if there was a specific story we were burning to tell,” Lena said in a statement. “I’ve missed these characters, but for a long time I couldn’t quite picture them in the present day.
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“Then, right around my 40th birthday [in May 2026], they started talking to me in the shower. And, as you may remember, once this fivesome starts talking it’s pretty hard to get them to stop.”
The cast of Girls pictured in the show’s penultimate episode
Naturally, all this nostalgia for Girls has got fans speculating about where the characters will be a decade on from when we last saw them. But it’s also had us reflecting on what the series’ stellar cast have been up to in the last 10 years, too…
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Lena Dunham
Megan Stalter and Lena Dunham in the Netflix rom-com Too Much
Girls catapulted Lena Dunham to international fame as the show’s lead actor, creator, writer and director.
Since the show’s final episode in 2017, her on-screen work has included playing the radical feminist Valerie Solanas in American Horror Story and Catherine “Gypsy” Share, a member of Charles Manson’s cult, in the film Once Upon A Time In Hollywood.
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As for her behind-the-scenes work, Lena has directed the movies Catherine Called Birdy and Sharp Stick, as well as the first ever episode of the British financial drama Industry.
In 2025, she also helmed the romantic comedy series Too Much for Netflix, in which she played a supporting character, alongside Megan Stalter and Will Sharpe as the the series’ leads.
The year that Girls came to an end, Allison played a key role in Jordan Peele’s game-changing and Oscar-winning horror movie Get Out, portraying Daniel Kaluuya’s on-screen girlfriend whose parents have a sinister secret.
You may have also seen her in series like The Mindy Project, Netflix’s reimagining of A Series Of Unfortunate Events and the romantic drama Fellow Travellers, playing the childhood friend of Matt Bomer’s Hawk.
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Jemima Kirke
Jemima Kirke as Hope Haddon in Sex Education
Jemima Kirke has been involved in an eclectic mix of projects since the Girls finale.
In addition to all of that, she has made a one-off appearance in Law & Order: Special Victims Unit, played Zayn Malik’s love interest in his Dusk Till Dawn music video and shared the screen with Jamie Dornan in the romantic drama Untogether.
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We also have to take a moment to celebrate Jemima as the meme queen that she is, inspiring not onebut two of our go-to reaction posts.
Zosia Mamet
Zosia Mamet in The Flight Attendant
Jennifer Rose Clasen/HBO
Since saying goodbye to Shoshanna, Zosia Mamet has continued to work on both the big and small screen.
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Already known thanks to her work in Mad Men, she later landed major roles in series like Unbreakable Kimmy Schmidt, Tales Of The City and Dickinson, in which she played Little Women author Louisa May Alcott.
Zosia and her co-stars in The Flight Attendant were nominated for a SAG Award for their performance in season one, and just this year, she played Nina Adler in Girls, which has already been compared favourably to Girls.
It’s fair to say Adam Driver‘s career has gone from strength to strength since Girls’ run.
Having already landed the role of Kylo Ren in Star Wars while the show was still on the air, he’s now a two-time Oscar nominee thanks to his work in the movies BlacKkKlansman and Marriage Story.
Adam went on to play Lady Gaga’s on-screen husband in House Of Gucci, Enzo Ferrari in Ferrari and the lead in Francis Ford Coppola’s ill-fated opus Megalopolis.
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Up next, he’s set to make his long-awaited MCU debut as the villainous Mister Sinister in the upcoming X-Men reboot.
Christopher Abbott
Christopher Abbott in Netflix’s East Of Eden
Shortly after Girls’ finale, Christopher Abbott landed roles in First Man, Vox Lux and Black Bear, which is where he met his future partner, Aubrey Plaza, with whom he now has a daughter.
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His other stand-out film work includes Poor Things, Kraven The Hunter, Wolf Man and The Testament Of Ann Lee, as well as the Apple TV+ drama The Crowded Room, which also featured Tom Holland and Amanda Seyfried.
Andrew Rannells
Andrew Rannells in the Great American Baking Show tent
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Already a Tony nominee by the time Girls came along, Andrew Rannells has continued his career in musical theatre, originating the role of Jim Bakker in the London production of Tammy Faye, as well as starring in a revival of The Boys In The Band on Broadway.
He has also racked up a string of impressive TV credits, voicing Matthew in the teen comedy Big Mouth, portraying Blair Pfaff in Black Monday, Kevin in Girls5Eva and Bradford Barton in Welcome to Chippendales.
Besides that, he’s popped up in the Will & Grace reboot, The Boys and Too Much, which reunited him with Lena, while his film work has included A Simple Favor, Ryan Murphy’s The Prom and Miss You, Love You.
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Outside of his acting work, Andrew is also now a co-host on the American version of The Great British Bake Off, known as The Great American Baking Show.
Alex Karpovsky
Alex Karpovsky as Rabbi Big Noah in Nobody Wants This
ERIN SIMKIN/NETFLIX
Following his time as the straight-talking Ray in Girls, Alex Karpovsky took a total 180 when he landed a role in the psychological thriller Homecoming.
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He later appeared in Curb Your Enthusiasm and Angelyn, and can currently be seen as Big Noah in the Netflix rom-com Nobody Wants This.
Next year, Alex’s film Allow Me To Destroy You, which he both wrote and directed, is also slated for release.
Ebon Moss-Bachrach
Ebon Moss-Bachrach as The Thing in The Fantastic Four: First Steps
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Long before he was winning Emmys for his performance as Richie in The Bear, Ebon Moss-Bachrach was probably best known as Marnie’s on-off husband Desi in Girls.
From there, he was cast in The Punisher and The Dropout, before being cast in The Bear, for which he’s now won two Emmys.
In Girls, Jake Lacy played Fran, a short-lived boyfriend of Lena Dunham’s Hannah.
After that, he landed roles in I’m Dying Up Here, Fosse/Verdon, High Fidelity and Mrs America, before the series he’s now probably best known for, The White Lotus.
For his work in the inaugural series of the sun-soaked anthology series, Jake was nominated for an Emmy, and he’s also since starred in Furious and All Her Fault.
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Jon Glaser
Jon Glaser as Jeremy in the American version of Ghosts
During his stint as Hannah’s neighbour Laird in Girls, Jon Glaser was also starring as Leslie Nope’s nemesis, Jeremy Jamm, in Parks And Recreation.
He later landed his own mockumentary show, Jon Glaser Loves Gear, before more recent roles in Single Drunk Female, Life & Beth, the animated series Wylde Pak and the US remake of Ghosts.
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Over the last decade, Jon has also appeared in films like Wine Country, Hustlers and the Oscar-nominated Don’t Look Up.
Gaby Hoffman
Gaby Hoffman in C’Mon C’Mon
Besides her work as Adam’s chaotic sister Caroline in Girls, Gaby Hoffman is perhaps most well-known for her performance in Transparent, as Ali Pfefferman.
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Her subsequent TV roles have included the sports drama Winning Time, the Netflix drama Eric and Rian Johnson’s murder mystery Poker Face.
In 2021, Gaby played Joaquin Phoenix’s on-screen sister in the film C’Mon, C’Mon, and more recently starred opposite Josh O’Connor in The Mastermind and Jeremy Allen White in Deliver Me From Nowhere, appearing as the mum of Bruce Springsteen.
Riz Ahmed
Riz Ahmed in Sound Of Metal
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Towards the end of Girls’ run, Riz Ahmed made two pivotal appearances as Paul-Louis, the father of Hannah’s son Grover.
He was also nominated for an Oscar for his performance in the film Sound Of Metal, a year before winning in the Best Live Action Short category.
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Riz’s other more recent film roles have included the superhero drama Venom, the star-studded disaster movie Digger and the 2025 adaptation of Hamlet, in which he took on the iconic title role.
Richard E Grant
Richard E Grant pictured during his brief stint on The Celebrity Traitors
In the last decade, his profile has only continued to grow, notably landing his first Oscar nomination for his performance in 2018’s Can You Ever Forgive Me?, before joining the Star Wars universe as Allegiant General Pryde.
His 2020s film credits have included the musical Everybody’s Talking About Jamie, Emerald Fennell’s class satire Saltburn, the action comedy Argylle and the Jane Austen adaptation Persuasion.
If social media is anything to go by, autumn is a time for ‘spooky vibes’ and leaning into Halloween aesthetics. For some of us, though, it is about getting real bloody cosy.
This means walks in the park to enjoy the natural autumn hues of the outdoors before coming home, snuggling under a blanket and tuning into films and tvs with warm tones and autumn ‘vibes’.
If this sounds like your preferred autumn experience, we have just the shows and films for you…
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Set against the backdrop of fall in Boston, Massachusetts, Good Will Hunting is the story of mathematics genius Will Hunting and his experiences working as a janitor in MIT. It’s inspiring, emotional and has stellar performances from Matt Damon and Robin Williams.
Good Will Hunting is available on Prime Video, Paramount and Netflix UK.
","type":"video","meta":{"author":"Shout! Studios","author_url":"https://www.youtube.com/channel/UCpHaAKu74UHvcYCi2g_PvBQ","cache_age":86400,"description":"Subscribe to SHOUTFACTORY: http://bit.ly/1nm0dKP \nFollow us on TWITTER: https://twitter.com/shoutfactory \nLike us on FACEBOOK: http://on.fb.me/1nEYhOx \n\nAcclaimed director Rob Reiner, screenwriter Nora Ephron, and stars Billy Crystal and Meg Ryan take you on a journey of love and friendship like no other in this magnificently witty love story that has been deservedly hailed as one of the greatest romantic comedies of all time.\n\nWill sex ruin a perfect relationship between a man and a woman? That’s what Harry Burns (Crystal) and Sally Albright (Ryan) debate while sharing a drive from Chicago to New York. Eleven years of friendship later, they’re still no closer to finding the answer. 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The crème de la crème of romcoms, When Harry Met Sally stars Meg Ryan and Billy Crystal as Harry Burns and Sally Albright as they find out whether men and women really can be “just friends”. It’s set in autumnal New York City and the fashion still inspires the best of autumn looks to this day.
When Harry Met Sally is available to stream on Prime Video.
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If you want cosy AND vintage vibes, You’ve Got Mail is the place to go. Written and directed by Nora Ephron who also wrote and directed When Harry Met Sally, You’ve Got Mail is a real enemies-to-lovers film and, yes, it’s fall in New York City. Delicious.
Advertisement
You’ve Got Mail is available to stream on HBO Max.
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Wes Anderson’s adaptation of the Roald Dahl classic is gorgeous autumn vibes, especially if you are a fan of stop-motion animation. It’s a warm family adventure and one that you can enjoy with the kids, too.
The Fantastic Mr Fox is available to stream on Prime Video.
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If you are looking for a little more whimsical Wes Anderson fun, look no further than Moonrise Kingdom. This coming-of-age story is fun, cosy and sweet as anything.
Moonrise Kingdom is available to rent on Prime Video from £3.49.
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Oh captain, my captain! Dead Poet’s Society offers one of Robin Williams’ best performances. It’s a coming-of-age story set in Vermont and celebrates embracing the moment, being yourself and the love of arts.
Advertisement
Dead Poet’s Society is available to stream on Disney Plus.
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Directed by Chris Columbus and starring Julia Roberts and Susan Sarandon, Stepmom navigates the difficulties of a fractured family in the face of terminal illness. It’s heartwarming, funny and heartbreaking.
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Little Women is available to stream on Netflix UK.
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Does it get more autumnal than Gilmore Girls? Probably not. It follows the lives of Lorelai Gilmore and her daughter Rory as they navigate life and love in the small town Stars Hollow. It is seemingly permanently autumn in this town and you know what? I’m not complaining.
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Gilmore Girls is available to stream on Disney Plus.
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A coming-of-age TV show based in the UK, Heartstopper follows the lives of Nick and Charlie as they slowly fall in love and face teenage hardships together. Heartstopper is real queer joy and in terms of autumn vibes? Well, there are animated falling leaves that appear throughout the show.
Over The Garden Wall is a cosy, slightly (SLIGHTLY) spooky animated show following brothers Wirt, voiced by Elijah Wood and Greg, who get lost in a timeless forest and must find their way home.
Over The Garden Wall is available to stream on Paramount.
","type":"video","meta":{"author":"Rotten Tomatoes TV","author_url":"https://www.youtube.com/channel/UCz1GPotHecuLngiLuY739QQ","cache_age":86400,"description":"Check out the new Only Murders in the Building Season 1 Trailer starring Selena Gomez! Let us know what you think in the comments below.\n► Learn more about this show on Rotten Tomatoes: https://www.rottentomatoes.com/tv/only_murders_in_the_building/s01?cmp=RTTV_YouTube_Desc\n\nWant to be notified of all the latest TV shows? Subscribe to the channel and click the bell icon to stay up to date.\n\nUS Air Date: August 31, 2021\nStarring: Selena Gomez, Steve Martin, Martin Short\nNetwork: Hulu\nSynopsis: Only Murders in the Building is a comedy that surrounds three strangers who share an obsession with true crime and suddenly find themselves wrapped up in one. When a murder occurs in their NYC apartment building, they are forced to work together to figure out what happened.\n\nWhat to Watch Next:\n► Certified Fresh TV: http://bit.ly/2FC8sQi\n► Top TV Dramas: http://bit.ly/2HSMnOs\n► Top TV Comedies: http://bit.ly/2ozqvP6\n► Most Anticipated Shows: http://bit.ly/2GQb8cq\n\nMore Rotten Tomatoes:\n► Subscribe to ROTTEN TOMATOES TV: http://bit.ly/2qTF6ZY\n► Subscribe to the ROTTEN TOMATOES NEWSLETTER: https://www.rottentomatoes.com/newsletter?cmp=RTYT_YouTube_Desc\n► Follow us on TWITTER: http://bit.ly/2mpschF\n► Like us on FACEBOOK: http://bit.ly/2COySMI\n► Follow us on INSTAGRAM: http://bit.ly/2FlxGC6\n\nRotten Tomatoes TV delivers Fresh TV at a click! Subscribe now for the best trailers, clips, sneak peeks, and binge guides for shows you love and the upcoming series and TV movies that should be on your radar.","options":{"_cc_load_policy":{"label":"Closed captions","value":false},"_end":{"label":"End on","placeholder":"ex.: 11, 1m10s","value":""},"_start":{"label":"Start from","placeholder":"ex.: 11, 1m10s","value":""}},"provider_name":"YouTube","thumbnail_height":720,"thumbnail_url":"https://i.ytimg.com/vi/uTtaNEy3PDw/maxresdefault.jpg","thumbnail_width":1280,"title":"Only Murders in the Building Season 1 Trailer | Rotten Tomatoes 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More of a cosy crime kind of person? Look no further than Only Murders in The Building. The show follows three kooky strangers who are obsessed with true crime and start a podcast together to solve a murder, yes you guessed it, in their building.
Advertisement
The show has guest stars such as Paul Rudd, Meryl Streep and Kumail Nanjiani and some real hijinks fun.
Only Murders In The Building is available to stream on Disney Plus.
An experimental drug developed at Michigan Medicine has reversed a serious form of fatty liver disease in animal studies by targeting an unexpected source of liver damage: the gut.
The compound, known as DT-109, works by reducing harmful gut bacteria, protecting the intestinal lining, and preventing inflammatory substances from reaching the liver. According to findings published in The Journal of Clinical Investigation, this approach successfully reversed metabolic dysfunction-associated steatohepatitis (MASH) in animal models, offering a promising new strategy for treating a disease that remains difficult to manage.
MASH affects approximately 7% of the world’s population. It is a severe form of fatty liver disease in which excess fat accumulates in the liver, causing inflammation and cellular damage. Over time, the condition can progress to cirrhosis, which involves extensive liver scarring, as well as liver cancer and liver failure. Although treatment options have improved in recent years, effective therapies remain limited.
“We see clear evidence that DT-109 protects the gut epithelial barrier, reducing the systemic influx of harmful microbial products that are thought to contribute to MASH development and progression,” said Eugene Chen, M.D., Ph.D., senior author of the study and Frederick G. L. Huetwell Professor of Cardiovascular Medicine at the University of Michigan Medical School.
“This compound shows benefits to the gastrointestinal system and has great potential as a treatment for MASH.”
How Harmful Gut Bacteria Can Trigger Liver Damage
Chen’s research team had previously demonstrated that DT-109, a glycine-based tripeptide, could improve MASH in animal studies. A tripeptide is a small molecule made from three amino acids, which are the building blocks of proteins. What remained unclear was exactly how the compound produced its protective effects.
The latest research provides an explanation, revealing how changes in gut bacteria can set off a chain reaction that damages the liver and how DT-109 can interrupt that process.
Before examining the drug’s effects, the scientists confirmed an important contributor to MASH: excessive growth of Clostridium perfringens, a bacterium that produces ammonia inside the intestines.
When ammonia levels rise, they can damage the gut’s protective inner lining. Normally, this intestinal barrier helps prevent potentially harmful substances from escaping the digestive tract and entering the bloodstream.
As the barrier weakens, however, toxins and other products generated by gut microbes can travel to the liver. Once there, they can provoke inflammation and activate immune defenses in ways that worsen liver damage.
One response involves the excessive activation of CD8+ T cells, immune cells that normally help the body destroy infected or abnormal cells. When these cells become overactive, they can contribute to the inflammatory processes associated with MASH.
The findings help explain why a disease centered in the liver can be strongly influenced by events occurring elsewhere in the digestive system.
Experimental Drug Repairs the Gut and Protects the Liver
Through a series of experiments, researchers discovered that DT-109 disrupts this damaging cycle by improving the intestinal environment and reinforcing the gut’s protective barrier.
In both mice and nonhuman primates, the compound reduced levels of Clostridium perfringens and lowered ammonia production in the intestines. These changes helped strengthen the intestinal lining, limiting the movement of harmful microbial substances into the body and reducing their potential to damage the liver.
The results were particularly encouraging in nonhuman primates, whose liver biology and gut microbial communities more closely resemble those of humans than those of mice. In these animals, DT-109 reduced liver inflammation and lessened the severity of MASH.
Together, the findings show how targeting harmful processes in the gut can produce beneficial effects in the liver, even though the drug acts primarily within the gastrointestinal system.
“DT-109 connects microbiota modulation with liver protection by restoring gut barrier integrity and limiting the systemic translocation of ammonia and other pro-inflammatory microbial products within the gut-liver axis,” said Jifeng Zhang, Ph.D., co-author and research professor of cardiovascular medicine at U-M Medical School.
“We also found that DT-109 primarily acts in the gastrointestinal tract, but its reach stretches much further.”
The gut-liver axis refers to the close biological relationship between the digestive tract and the liver. Substances absorbed from the intestines travel to the liver through the bloodstream, making liver health particularly sensitive to changes in gut bacteria and intestinal barrier function.
By targeting this connection, DT-109 may offer a way to address some of the processes driving liver inflammation rather than focusing exclusively on damage that has already occurred.
Potential Benefits Beyond Fatty Liver Disease
Researchers believe the compound’s ability to protect the intestinal barrier could make it useful against other conditions involving inflammation and metabolic dysfunction.
Previous research has shown that DT-109 can reduce the formation of atherosclerotic plaques and prevent vascular calcification in nonhuman primates.
Atherosclerotic plaques are deposits of fat and other substances that accumulate inside artery walls, potentially restricting blood flow and increasing the risk of cardiovascular problems. Vascular calcification occurs when calcium builds up in blood vessel walls, making them less flexible and contributing to cardiovascular disease.
These findings suggest that DT-109 could eventually have applications in treating both liver and cardiovascular conditions, an important possibility because metabolic disorders often affect multiple organs.
The researchers are also interested in whether the compound could help people with inflammatory bowel disease (IBD), a group of chronic conditions that includes Crohn’s disease and ulcerative colitis.
Because problems with the intestinal barrier are associated with several gastrointestinal disorders, a treatment that strengthens this barrier might have benefits beyond protecting the liver. However, additional research will be needed to determine whether DT-109 is effective against these conditions.
A Promising Treatment That Still Needs Human Trials
Despite the encouraging results, DT-109 remains an experimental treatment. Its ability to reverse MASH has been demonstrated in animal models, but researchers have not yet established whether it can safely and effectively produce similar benefits in humans.
The next phase of research will involve further evaluation of the compound, with the goal of advancing it toward clinical trials. Those studies will be essential for determining its safety, appropriate use, and potential effectiveness in patients.
“This study presents novel evidence about the pathogenesis of MASH and provides excitement about a therapeutic avenue to explore for a condition that remains difficult to treat,” said Elliot Tapper, M.D., Academic Director of Hepatology at Michigan Medicine.
“What patients with MASH need is a safe and effective therapy capable of improving their liver and heart health – of course we are excited about these developments.”
The discovery highlights an important shift in how scientists are approaching fatty liver disease. By addressing harmful gut bacteria and restoring the intestinal barrier, researchers may be able to protect the liver through a treatment that acts primarily outside the organ itself.
If future human studies confirm the benefits seen in animals, DT-109 could offer a new therapeutic option for patients with severe fatty liver disease while potentially addressing cardiovascular complications as well.
Funding and Disclosures
Ying Zhao, Oren Rom, Jifeng Zhang, and Y. Eugene Chen are listed as inventors on a patent application (Tripeptides and treatment of metabolic, cardiovascular, and inflammatory disorders).
Chen is also an inventor of DT-109. The University of Michigan holds the patent for the compound and has licensed it to Diapin Therapeutics. Both Chen and the university have an ownership interest in Diapin, which supplied DT-109 for the research and is continuing its development.
The human study protocol, all amendments, and the informed consent form received approval from the Institutional Review Boards at the participating sites. These included the First Affiliated Hospital of Xi’an Jiaotong University (approval number: XJTU1AF2023LSK330), the Institutional Review Board of Jinan University (approval number: 2016-017), and the University of Hong Kong/Hospital Authority Hong Kong West Cluster (approval number: UW 20-700).
All experimental procedures involving nonhuman primates were approved by the Laboratory Animal Care Committee of Xi’an Jiaotong University (approval number: 20191278) and the Institutional Animal Care and Use Committee of Spring Biological Technology Development Co., Ltd. (approval number: 201901). The study was conducted in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals.
A good night’s sleep does much more than leave you feeling refreshed. During deep sleep, the body releases growth hormone, a powerful chemical messenger that helps build muscle, strengthen bones, and regulate fat metabolism. For teenagers, getting enough sleep is especially important because growth hormone plays a major role in reaching their full height potential.
Scientists have long known that insufficient sleep can interfere with growth hormone production. What remained unclear was exactly how the brain controls this process, particularly during non-REM sleep, the deep, restorative stage that typically dominates the earlier part of the night.
Now, researchers at the University of California, Berkeley, have uncovered the brain circuitry behind this relationship. In a study published in the journal Cell, the team identified the neurons that regulate growth hormone release during sleep and discovered a previously unknown feedback system that helps maintain a delicate balance between hormone levels and wakefulness.
The discovery reveals that the relationship works in both directions. Sleep stimulates growth hormone production, but growth hormone also sends signals back to the brain that influence when we wake up.
The findings could eventually help scientists develop new approaches to treating sleep disorders associated with metabolic diseases such as diabetes, as well as neurological conditions including Parkinson’s and Alzheimer’s.
“People know that growth hormone release is tightly related to sleep, but only through drawing blood and checking growth hormone levels during sleep,” said study first author Xinlu Ding, a postdoctoral fellow in UC Berkeley’s Department of Neuroscience and the Helen Wills Neuroscience Institute. “We’re actually directly recording neural activity in mice to see what’s going on. We are providing a basic circuit to work on in the future to develop different treatments.”
Why Deep Sleep Matters for Growth and Metabolism
Growth hormone is best known for its role in childhood development, but its importance extends well into adulthood. It supports the maintenance of muscle and bone, helps the body regulate how it uses stored fat, and influences blood sugar levels.
When sleep is consistently disrupted, growth hormone regulation can suffer. Because this hormone helps control glucose and fat metabolism, inadequate sleep may contribute to an increased risk of obesity, diabetes, and cardiovascular disease.
To understand how the brain coordinates these processes, the Berkeley researchers focused on a region called the hypothalamus. Located deep within the brain, this small but essential control center helps regulate hunger, body temperature, hormone production, and the daily cycle of sleeping and waking. Its basic functions have been preserved throughout mammalian evolution.
Within the hypothalamus, the researchers examined neurons that produce growth hormone-releasing hormone (GHRH) and two distinct types of neurons that produce somatostatin.
These chemical messengers have opposing functions. GHRH encourages growth hormone secretion, while somatostatin suppresses it. Together, they help control how much growth hormone enters the bloodstream, largely by regulating its release from the pituitary gland, a small hormone-producing structure at the base of the brain.
The scientists also investigated how growth hormone influences the locus coeruleus, a region in the brainstem involved in alertness, attention, thinking, and the drive to explore new or unfamiliar experiences.
Disruptions in the activity of this region have been linked to several psychiatric and neurological disorders.
“Understanding the neural circuit for growth hormone release could eventually point toward new hormonal therapies to improve sleep quality or restore normal growth hormone balance,” said Daniel Silverman, a UC Berkeley postdoctoral fellow and study co-author. “There are some experimental gene therapies where you target a specific cell type. This circuit could be a novel handle to try to dial back the excitability of the locus coeruleus, which hasn’t been talked about before.”
Scientists Map the Brain Circuit That Controls Growth Hormone
The research was conducted in the laboratory of Yang Dan, a professor of neuroscience and of molecular and cell biology at UC Berkeley.
To investigate how the circuitry works, the team studied mice using electrodes implanted in their brains. The scientists recorded neural activity while using light to stimulate specific neurons in the hypothalamus, allowing them to observe how different parts of the system responded.
Mice are particularly useful for studying sleep regulation because their sleep patterns differ significantly from those of humans. Rather than sleeping through one long stretch each night, mice typically sleep in brief episodes lasting only several minutes, scattered throughout the day and night.
This gave the researchers repeated opportunities to examine how neural activity and growth hormone regulation changed as the animals moved between sleeping and waking.
Using advanced techniques to trace connections between brain cells, the team discovered that GHRH and somatostatin behave differently depending on the stage of sleep.
During rapid eye movement (REM) sleep, the stage commonly associated with vivid dreaming, activity involving both GHRH and somatostatin increases. Although these hormones normally exert opposing effects, their coordinated activity during this stage contributes to increased growth hormone release.
During non-REM sleep, the pattern changes. Somatostatin activity decreases, reducing its inhibitory influence, while GHRH activity rises moderately. This combination also promotes growth hormone secretion.
The discovery helps explain how different sleep stages can support the release of the same essential hormone through distinct patterns of brain activity.
Growth Hormone Also Helps Control When We Wake Up
Perhaps the most surprising finding was that growth hormone does not simply respond to signals from the sleeping brain. It also influences the brain circuits that control wakefulness.
As growth hormone gradually builds up during sleep, it stimulates neurons in the locus coeruleus, increasing their activity and helping promote the transition toward waking.
This creates a feedback loop in which sleep encourages growth hormone release, and the resulting hormone activity helps regulate the sleep-wake cycle.
The researchers also identified an unexpected complication. Although greater activity in the locus coeruleus generally promotes alertness, excessive stimulation can have the opposite effect.
In an earlier study published the same year, Silverman demonstrated that when neurons in this region become overexcited, they can paradoxically promote sleepiness rather than wakefulness.
Together, these findings reveal a carefully regulated system in which the brain must balance competing signals to maintain healthy sleep and hormone activity.
Scientists describe this type of self-regulating process as homeostasis, the body’s ability to maintain stable internal conditions even as its environment and physiological demands change.
“This suggests that sleep and growth hormone form a tightly balanced system: Too little sleep reduces growth hormone release, and too much growth hormone can in turn push the brain toward wakefulness,” Silverman said. “Sleep drives growth hormone release, and growth hormone feeds back to regulate wakefulness, and this balance is essential for growth, repair and metabolic health.”
A Surprising Connection Between Sleep and Brain Health
The newly identified feedback system may have implications that extend beyond physical growth and metabolism.
Because the locus coeruleus helps regulate attention, alertness, and cognitive function, growth hormone’s influence on this region suggests it could also play a role in how effectively the brain functions after waking.
This raises the possibility that maintaining healthy sleep and growth hormone rhythms may support both physical recovery and mental performance.
“Growth hormone not only helps you build your muscle and bones and reduce your fat tissue, but may also have cognitive benefits, promoting your overall arousal level when you wake up,” Ding said.
By identifying the specific brain cells and signaling pathways involved, the researchers have provided a foundation for exploring therapies that target disrupted sleep and hormone regulation.
Such approaches could eventually prove useful for people with sleep disturbances related to metabolic disorders or neurological diseases. However, the experiments were conducted in mice, and additional research will be needed to determine how these mechanisms operate in humans and whether they can be safely targeted with treatments.
The findings underscore a fundamental principle of sleep biology: Rest is not simply a period when the brain switches off. It is an active, carefully coordinated process in which hormones and neural circuits constantly communicate to support growth, repair, metabolism, and wakefulness.
Research Funding and Contributors
The research was supported by the Howard Hughes Medical Institute (HHMI), which supported Dan as an HHMI investigator until the year of the study’s publication, and the Pivotal Life Sciences Chancellor’s Chair fund.
Dan holds the Pivotal Life Sciences Chancellor’s Chair in Neuroscience.
Additional co-authors include Peng Zhong, Bing Li, Chenyan Ma, Lihui Lu, Grace Jiang, Zhe Zhang, Xiaolin Huang, Xun Tu, and Zhiyu Melissa Tian of UC Berkeley, along with Fuu-Jiun Hwang and Jun Ding of Stanford University.
In 1960, Science, one of the world’s leading science journals, published an article with an unambiguous title: Doomsday: Friday, 13 November, A.D. 2026. It predicted that on this future date — less than a month from today — the human population would approach infinity and effectively annihilate itself.
The outlandishness of the claim landed the article widespread public attention. More surprisingly — because its underlying research and math seemed sound — it also received careful and sustained scientific attention.
The authors — Heinz von Foerster, an Austrian-American professor and cybernetics expert and two of his students, Patricia M. Mora and Lawrence W. Amiot — argued that human populations are exceptional and might grow beyond an exponential rate, at an ever-increasing one.
“Our great-great-grandchildren will not starve,” they argued. “They will be squeezed to death.”
The article was regularly cited, and its predictions appeared remarkably accurate — until around 1993, halfway to the predicted “doomsday,” when the global population began falling behind its forecasts.
Today, the global birth rate is slightly less than half what it was in 1960. Hopefully, we will all wake up on Nov. 13 to an ordinary day. Nonetheless, this article remains exemplary for blending rigorous science with the art of stagecraft to staggering effect.
In their article, however, von Foerster and his co-authors argued that as far as populations go, humans may be exceptional.
Given our capacity to communicate and form “coalitions” that help us resolve problems, rising population density might simply mean more opportunities for collaboration, so that our numbers might grow not only beyond an exponential rate but at an ever-increasing one.
They then used 24 estimates of the world population stretching across the past 2,000 years to show that human numbers have in fact continually outpaced expectations. All this was presented in calm, scientific prose and aided by dense mathematical equations.
‘Squeezed to death’
Von Foerster and his co-authors then projected these historical figures into the future, calculating that thanks to ever-increasing growth, in the year 2026 our numbers would near infinity.
Thankfully, the same capacity for collaboration that assisted our species’ development throughout history could now avert this catastrophe. Since we are unlikely to want to reduce our life spans, they concluded, we should work together to reduce the global birth rate by half.
This publication caused an immediate stir. There were stories in Time and The New York Times. It became the subject of a series of Pogo comic strips and many commentators took the article as strictly a tongue-in-cheek comment on population fears.
A population explosion
Rather than the story dying out, a funny thing happened. When Science published letters to the editor from mathematicians and demographers attacking von Foerster and his colleagues’ work — calling it “ridiculous” and “manifestly absurd” — the authors responded with spirited defenses that doubled down on the underlying math and its conclusions.
Throughout the 1960s through to the 1980s, the “doomsday” equation became regularly cited — usually at face value — in textbooks on genetics, ecology and demography.
It appeared in stranger places, too. In a 1963 Canadian Parliamentary committee, for example, a witness from the chemical industry prominently cited it as reason chemical pesticides were required: to feed the approaching population explosion. In a 1971 U.S. Supreme Court abortion case leading up to Roe v. Wade, it was cited as why there was no compelling reason for the government to favor increased population.
The doomsday idea persisted in part because its predictions for future populations turned out to be highly accurate — at least for a while. Its core equation yielded projections that were better than those of most demographers throughout the 1970s and 1980s.
Only around 1993 did that accuracy begin to falter and the global population began falling behind the forecasts — because the world began to do what von Foerster and his colleagues recommended it do. Today, the global birth rate is slightly less than half the 1960 rate.
Science and stagecraft
We will probably not all wake up on Friday, Nov. 13 “squeezed to death.” But before simply moving on — prepping for the next doomsday scenario — it is worth asking what we can learn from this one.
For me, the lesson is in how we present our beliefs to the world. Heinz von Foerster was, at one point in his life, a stage magician. Borrowing the classic language of stagecraft, an effective illusion relies on three parts: the setup, the extraordinary turn and the final reveal that returns the situation to normal.
Von Foerster and his co-authors’ article gained attention because it was an ordinary scientific article wrapped in an extraordinary title and conclusion. It retained significance because it was firmly grounded in research and argument.
To draw the world’s attention to a serious matter by way of absurdity — that’s a good trick.
Research into menopause and perimenopause is vastly improving. This means that while we may have always associated mood swings and hot flushes with these life changes, we have learned that they can actually fundamentally change the body.
While this is very hopeful for future generations of women, a new survey conducted by Holland and Barrett in partnership with Menopause Mandate has found that 46% of women are still having perimenopause and menopause symptoms dismissed by other women.
Additionally, the research found an age disparity with younger women entering perimenopause feeling the most isolated. Over half (51% of 30–44-year-olds have reported symptom doubt, compared to 40 per cent of those aged 55 or over.
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Women are dedicating an average of 2.3 hours a week to ‘menopause admin’
Beyond managing their symptoms, women are dedicating on average over two hours a week to menopause admin. This includes:
Menopause comes with a range of symptoms including difficulty concentrating, electric shocks on the skin, vaginal atrophy and recurring urinary tract infections (UTIs).
A full range of potential menopause symptoms can be found on The Menopause Charity’s website but it’s fair to say, we are likely dismissing one another’s symptoms because we simply don’t know the extent of the changes menopause can bring.
Laura Biggs, Founding Director at Menopause Mandate, comments: “Perimenopause and menopause can affect women in very different ways, and symptoms can change over time. It’s so important that women know what they might experience and can find help and support when they need it.
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“Since launching in 2022, the Menopause Mandate nurse helpline has offered free advice from trained professionals.”
A frisson of excitement ran through Westminster this week.
After two opinion polls put Labour and the Conservatives in first and second place, the inevitable question followed: “Is two-party politics back?”
Just a year ago, the prospect of the next election being a straight shootout between the two traditional parties would have seemed fanciful.
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Reform UK were still ahead with every pollster, while the Greens were continuing their resurgence under their new leader, Zack Polanski.
May’s local elections seemed to confirm that a new era of multi-party politics in the UK was here to stay.
Reform gained nearly 1,500 new councillors, while the Greens saw their town hall representation soar by more than 800 seats.
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At the same time, Labour – who were still in the doldrums under the leadership of Keir Starmer – lost 1,498 councillors, and the Tories 563.
Since then, however, British politics has once again been turned on its head.
Labour’s decision to dump Keir Starmer and replace him with Andy Burnham has so far been vindicated, with the party enjoying the novelty of being led by someone that voters actually like.
At the same time, Reform have been hit by a series of scandals and controversies which have led to the party’s popularity plummeting.
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Nigel Farage still awaits the result of the parliamentary standards commissioner’s investigation into his failure to declare a £5 million gift from crypto billionaire Christopher Harborne.
The Metropolitan Police is also investigating the outcome of an undercover Channel 4 documentary in which senior Reform officials appeared to be willing to break electoral law to get money from a foreign donor.
According to a poll of polls by Election Maps UK, Reform have slumped from 27.5% at the end of May to 22.7% now.
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Over the same period, Labour’s own standings have soared from 19.6% to 27.7%. The last time they led Reform by 5 points was at the end of 2024.
As Farage and Polanski’s popularity has waned, Kemi Badenoch’s has continued to rise, and there are now signs that she is finally dragging the battered Tory brand with her.
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Can Nigel Farage turn around Reform’s fortunes?
via Associated Press
But leading pollsters who spoke to HuffPost UK this week explained why it is too early to write off Reform and the Greens.
Luke Tryl, UK director of More in Common, said: “While the two-party system may not be dead and buried, it certainly remains in a weak state.
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“An election held tomorrow would likely still produce the most fragmented results in history, and our latest poll suggests that no party would come close to a majority, and a coalition would be the most likely outcome.
“Trust in mainstream politics remains at a dire low. Unless the two major parties can reassure Britons that they are listening to their concerns, are trying to do something about them, and are actually capable of doing so, this will continue to be the case.”
Chris Hopkins, political research director at Savanta, said “any talk of a return to two-party politics remains premature”.
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“The improvement in the standing of Labour and the Conservatives remains muted, rarely combining for more than 50% of the vote in the latest round of opinion polls,” he said.
“This remains a far cry from recent general elections, especially 2017, where the Conservatives and Labour received a whopping 82% of the overall vote.
“Of course, things can still change very quickly in British politics so only a fool would completely rule out a return to two-party politics.
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“But if an election were tomorrow, Reform and the Greens would represent significantly greater challenges in constituencies up and down the country for the main two parties than ever before.
“That, coupled with the national strength of the SNP in Scotland and Plaid Cymru in Wales, means that multi-party politics is unlikely to be going anywhere anytime soon.”
Zack Polanski speaks with supporters during the Holborn and St Pancras by-election campaign.
SOPA Images SOPA Images/LightRocket via Gett
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Keiran Pedley of Ipsos UK said “the battle for hearts and minds on the right” was yet to be won by either the Tories or Reform, who remain strong in the north of England and the Midlands.
“As long as Nigel Farage is around it is hard to see them going anywhere and what we don’t know is whether Reform today are at a low ebb that they recover from, or if the Conservative momentum continues,” Pedley said.
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With a difficult Budget less than two weeks away, Burnham and Labour’s current popularity may well prove to be short-lived if energy bills soar and the economy takes a turn for the even worse.
Badenoch, meanwhile, still faces an enormous challenge in trying to make the Tories competitive come the next election, give their hammering last time around.
As Pedley pointed out: “We can hardly declare a return to the two party system when five parties are polling in double digits and nationalist parties are in government in Scotland and Wales.”
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Listen to Commons People, the podcast that makes politics easy. Every week, Kevin Schofield and Kate Nicholson unpack the week’s biggest stories to keep you informed. Join us for straightforward analysis of what’s going on at Westminster.