Earlier studies had raised concerns that acetaminophen (Tylenol) given during infancy might be connected to eczema, asthma, or other health conditions later in childhood.

“Our study found that paracetamol and ibuprofen are incredibly safe to use in young children,” says lead researcher Professor Stuart Dalziel, Cure Kids Chair of Child Health Research at Waipapa Taumata Rau, University of Auckland, and Pediatrician at Starship Children’s Hospital.

Dalziel notes that acetaminophen and ibuprofen are among the medicines most often prescribed or purchased over the counter for babies around the world.

“These results give parents and health professionals high confidence to continue to use these important medications.”

Nearly 4,000 Babies Took Part

The trial followed almost 4,000 babies from birth across New Zealand. Half were randomly assigned to receive acetaminophen when medication was needed for fever or pain during the first year of life. The other half were assigned to receive ibuprofen.

At regular points throughout the study, parents were asked whether their children had experienced eczema, asthma symptoms, or bronchiolitis. The research team also reviewed prescription information and hospital records.

The findings from the first year of follow-up have now been analyzed and published in The Lancet Child & Adolescent Health.

No Significant Difference in Eczema or Bronchiolitis

About 16 percent of babies in the acetaminophen group developed eczema, compared with 15 percent in the ibuprofen group. Bronchiolitis affected about five percent of children in each group.

Researchers found that these differences were not statistically significant. Serious side effects were uncommon, and none were attributed to either medication.

Overall, the results showed no association between acetaminophen or ibuprofen and eczema or bronchiolitis. The findings also confirmed that both medicines were safe to use during infancy.

This is the first randomized controlled trial considered the gold standard for research to directly examine this question.

A Long-Term Study of Childhood Health

The findings are part of a larger research project called the ‘Paracetamol and Ibuprofen in the Primary Prevention of Asthma in Tamariki (PIPPA Tamariki)’ study.

PIPPA Tamariki is the largest clinical trial involving children ever carried out in New Zealand. Participants are being monitored from birth until they reach age six.

The research team plans to publish results from the children at age three, followed by additional findings when they reach age six.

The broader goal is to determine whether acetaminophen use during the first year of life is connected to health conditions that cannot be diagnosed reliably until children are older.

“We know that two-thirds of children who are wheezy at age three years don’t develop asthma by age six,” says Dalziel.

“Thus we need to wait until school age to ultimately test if paracetamol in the first year of life causes asthma.”

Developmental conditions such as autism and attention deficit hyperactivity disorder (ADHD) also tend to be identified more accurately as children grow older.

Lead author Dr. Eunicia Tan, a senior lecturer at the University of Auckland and emergency physician at Middlemore Hospital, says, “Ultimately, the study will provide important evidence regarding the link between paracetamol use and asthma, eczema, hay fever, and developmental disorders, such as autism and ADHD.”

The research was funded by the Health Research Council of New Zealand and Cure Kids. It was conducted by the University of Auckland and the Medical Research Institute of New Zealand, Wellington.

Because the black hole was not actively consuming matter, it would ordinarily have remained invisible. Its location was exposed only when it tore apart a passing star, producing a brief but powerful burst of light. The findings were published in The Astrophysical Journal Letters on July 27, 2026.

“This is a novel result. What’s new is that, until now, we’ve started with the assumption that supermassive black holes reside in the centers of massive galaxies,” said study co-author Suvi Gezari, an associate professor of astronomy at UMD. “This discovery will have a huge impact. It means that we’re going to find many more examples of wandering black holes, and we can understand how galaxies and their black holes merge and build up over time.”

A Long Predicted Wandering Black Hole

Scientists have long predicted that some black holes could be displaced toward the outer regions of galaxies during galactic collisions and mergers. These objects are often described as “wandering” black holes.

Finding them is extremely difficult. Many are quiescent, meaning they are not consuming nearby material or producing detectable light. As a result, they can move through galactic outskirts without being noticed by telescopes on Earth.

Researchers first detected the quiescent black hole using the Zwicky Transient Facility (ZTF), which “searches the whole universe,” according to study lead author Robert David Stein. Stein is a Neil Gehrels Prize Postdoctoral Fellow at the Joint Space-Science Institute, a research partnership between UMD’s Departments of Astronomy and Physics and NASA’s Goddard Space Flight Center (GSFC).

Artificial Intelligence Finds a Stellar Flare

Using two telescopes at Palomar Observatory in San Diego County, California, ZTF surveys the entire northern sky once every two days. The observatory records hundreds of thousands of changing celestial events each night, making it impractical for researchers to examine every event individually for signs of a black hole.

To handle that enormous volume of data, the team created an artificial intelligence (AI) program trained to recognize the distinctive light pattern produced when a black hole destroys a star. This event, known as a tidal disruption event, occurs when a star passes close enough to be pulled apart by a black hole’s gravity.

Astronomers have documented many tidal disruption events near the centers of galaxies. The new AI system was designed to search for the same types of flares across the entire sky, including locations far from galactic centers.

The UMD researchers began operating the program in August 2025. Only three months later, it identified the event that led them to the wandering black hole.

“I remember the moment we discovered it very clearly. It was a Saturday, and everyone was very excited to be messaging. We dropped everything and started triggering all kinds of other instruments to get more data,” Stein said. “We weren’t really sure we would be successful so quickly, so it’s amazing that we found one so fast.”

A Supermassive Black Hole Far From the Galactic Center

The black hole sits 9.3 kiloparsecs (about 30,000 light-years) from the center of its galaxy. Its mass is comparable to that of the supermassive black hole located at the center of the Milky Way.

What makes the object especially puzzling is the apparent absence of a visible galaxy surrounding it, according to study co-author and UMD Astronomy Professor Sylvain Veilleux.

“To have such a big black hole outside of a galaxy is surprising to me,” he said. “There should be a Milky Way-like object around it — and that’s definitely not the case.”

Researchers believe the black hole’s unusual position is probably connected to a past collision between galaxies.

One explanation is that a large galaxy absorbed a smaller companion. Over time, the larger galaxy may have stripped away nearly all of the smaller galaxy’s stars, leaving only its dense central core and black hole behind.

Another possibility involves a more chaotic encounter among three black holes. A galaxy may already have contained two black holes orbiting closely around one another at its center, a system known as a binary black hole. If a third black hole arrived during another galactic merger, the resulting three-body interaction could have expelled the smallest black hole from the center.

Additional observations of the tidal disruption event may help researchers determine which explanation is more likely.

Dormant Black Holes Could Be Common

Understanding inactive black holes is important because most known black holes are dormant, including the one at the center of the Milky Way.

Scientists do not yet know whether wandering black holes exist in the outer regions of our own galaxy. However, Stein said there is no reason to worry about encountering one.

“We’re very unlikely to meet one, at least in our lifetime.”

The research team is continuing to search the sky for additional wandering black holes. Finding more of them could help scientists “understand how galaxies form and how many black holes are whizzing around,” Stein said.

The discovery also demonstrates that these elusive objects can be identified with conventional sky surveys combined with machine learning, rather than relying exclusively on more expensive observational methods.

“It is super exciting,” Gezari explained. “It’s an example of machine learning opening up a whole new area of research.”

New Observatories Could Find Hundreds More

Stein expects future searches with the NSF-DOE Vera C. Rubin Observatory to identify dozens or possibly hundreds of wandering black holes each year. The Chile-based observatory debuted last June and captures exceptionally detailed views of the sky with the world’s largest digital camera.

Veilleux also pointed to the Lowell Discovery Telescope and its Rapid infrared IMAger-Spectrometer, which debuted in June 2025 as a collaboration between GSFC, the UMD Department of Astronomy and Lowell Observatory. The instrument could enable scientists to detect tidal disruption events at far greater distances from Earth than previously thought possible.

“This is the strongest case of a wandering black hole that we know,” Veilleux said. “This is going to set the standard.”

UMD Astronomy Adjunct Professor Stephen Bradley Cenko and postdoctoral associate Jillian Chin Rastinejad coauthored the study with Stein, Gezari and Veilleux.

This research was funded by the U.S. National Science Foundation (Award Nos. 2407588 and 1106171); the Gordon and Betty Moore Foundation through the Data-Driven Investigator Program and a dedicated grant to SkyPortal; the W. M. Keck Foundation; the Heising-Simons Foundation; William and Marina Kast; the University of California Observatories; Google; Deutsche Forschungsgemeinschaft under Germany’s Excellence Strategy, EXC-2094/2, 390783311.939; the Australian Research Council under ARC LIEF grant LE130100104; Astronomy Australia Limited and the Australian Government through the Commonwealth’s Education Investment Fund and National Collaborative Research Infrastructure Strategy, particularly the National eResearch Collaboration Tools and Resources and the Australian National Data Service Projects. This content does not necessarily reflect the views of these parties and organizations.

A study using zebrafish found that altered gene activity can cause minerals to accumulate within the spine. This process resembles bone forming where it should not, eventually making spinal tissue unusually hard.

Researchers say the results reveal several biological processes that could become targets for future back pain treatments. The work also indicates that zebrafish may provide a useful model for testing potential therapies.

Why Spinal Discs Break Down

Most people experience back pain at some point. A major cause is the progressive deterioration of the discs that cushion the bones of the spine, a condition called intervertebral disc degeneration (IVDD).

Although IVDD is widespread and places a considerable burden on patients and health care systems, no medications can currently halt or reverse its progression. Surgery is still the only available long-term treatment.

Inherited factors are known to influence a person’s risk of developing IVDD. Previous research has repeatedly connected early disc problems to a gene associated with collagen IX, a protein that helps bind together the structural fibers inside spinal discs.

To investigate how defects in this gene might cause disc disease, researchers from the Universities of Edinburgh and Bristol studied zebrafish bred without a functioning copy of it.

Zebrafish Developed Human-Like Spinal Damage

As the zebrafish grew older, they developed spinal abnormalities that closely resembled disc disease in people. Their vertebrae fused, while mineral deposits caused the tissue between the bones to become abnormally hard.

The researchers discovered that this mineralization did not begin immediately. First, a supportive scaffold layer within the developing spine started to deteriorate. Mineral deposits appeared only after this early structural damage had occurred.

The team then examined patterns of gene activity in the fish to determine which genes had become more or less active.

Their analysis revealed problems with fat processing and with mTOR, a pathway that regulates growth. They also found changes involving phosphate control and vitamin A signaling. Each of these processes has been associated with abnormal mineral accumulation.

Existing Osteoporosis Drug Reduced Mineral Buildup

The researchers also identified several approaches that reduced the spinal damage.

A bisphosphonate, a type of bone-protecting medication already used to treat osteoporosis, prevented minerals from accumulating. Spinal fusion was also reduced when the fish received less food or were treated with drugs that suppressed fat metabolism.

According to the researchers, the results highlight phosphate regulation and fat metabolism as especially promising areas for the development of future medicines.

The study was funded by Arthritis UK and BBSRC and published in the journal Communications Biology.

New Possibilities Beyond Surgery

Study lead, Dr. Erika Kague, from the University of Edinburgh’s Institute of Genetics and Cancer, said: “For decades, surgery has been the only real answer for disc disease. By understanding the biology that drives the spine to harden, our zebrafish studies point to several ways of slowing it down, including a drug already used safely in patients. There’s more work to do, but for a condition that’s affected people for generations without a treatment in sight, this is super exciting.”

Dr. Caroline Aylott, Head of Research Delivery at Arthritis UK, said: “For the 9.5 million people across the UK living with back pain, this research brings fresh hope that potential new therapeutic approaches are on the horizon.

“We are proud to fund research that is unlocking the science behind the processes leading to spinal disc degeneration. Back pain is one of the UK’s most common conditions that has blighted millions over generations. Dr. Erika Kague and her team at the University of Edinburgh have uncovered important genetic evidence that could pave the way for new treatments, bringing us one step closer to a future where fewer people have to live with the daily pain and challenges that back pain can bring.”

Dr. Jef Grainger, Executive Director of Bioscience Advancing Knowledge at BBSRC, said: “This research shows how publicly funded discovery bioscience can generate the knowledge needed to address major health challenges. By revealing new knowledge of how healthy biological processes break down in aging-related spinal disc degeneration, the study opens up promising avenues for future treatment development. It’s a great example of how BBSRC-supported research helps turn scientific discovery into knowledge and innovations that have the potential to improve people’s lives.”